Titel:

Prevalence of vitamin B-12 deficiency and its relation to macrocytic anemia in an undiagnosed patient population (n=161,548) in the Rotterdam Area, the Netherlands

Plattel & Brito et al 2016 

Introduction:

Vitamin B12 deficiency is known as an elderly disease. Macrocytic anemia is commonly used as a diagnostic criterion for B-12 deficiency.

Method:

I. Prevalence of low (serum B12 <148 pmol/L) and low-normal B12 status (148-221 pmol/L) was calculated from data collected at Star-MDC (2010-2013) in a undiagnosed patient population (Rotterdam NL, n=161,548).

II. Macrocytic anemia (MCV>100 fL; Hb<7.5 mmol/L women, Hb<8.5 men) was assessed in relation to low B12 and low serum folate (<6.8 nmol/L) in a subsample of 59,231 individuals.

Results:

I. High prevalence of low and low-normal B-12 was found in the overall population (24.3% and 34.3%, respectively, total=58.6%) and was consistently high between genders and across years of collection. Children ≤10y presented a lower prevalence (p<0.0001) of low and low-normal B-12 (11.6%) than adolescents (10-20y, 50.8%), adults (20-65y, 58.7%) and the elderly (>65y, 60.2%).

II. The overall subsample presented 24.7% low B-12, 8.1% low folate, 22.2% anemia and 3.7% macrocytosis, 1.3% macrocytic anemia. When B-12 was low (p<0.0001) only 1.9% presented macrocytic anemia vs.15.6% when folate was low. Categories of low and normal B-12 with low folate presented higher prevalence (p<0.0001) of macrocytic anemia (4.65% and 2.73%, respectively) than those with normal folate (1.43% and 0.96%).

Conclusions:

Low and low-normal B12 were highly prevalent across age groups. Macrocytic anemia was low and was mainly explained by low folate. This suggests that B-12 deficiency is not limited to the elderly and that macrocytic anemia is a poor indicator of B12 and folate deficiency.

[The abstract is presented during a oral presentation by Clara Plattel during The International Vitamin Conference / Copenhagen May 2016, hosted by the University of Copenhagen and Aarhus]

Results

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In samenwerking met het Zilveren Kruis, interne afdeling medisch specialistische zorg en klantencontact balie, is er een communicatie campagne in gang gezet om de naamsverwarring en de daarmee gepaard gaande verwarring over de polis-afhankelijke vergoedingen, uit de wereld te helpen zodat patiënten bij de klantenservice de juiste informatie voorgeschoteld krijgen: Alle zorgverzekeraars vergoeden polis afhankelijk de facturen van het B12 Institute, dus ook het Zilveren Kruis.lees verder...
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